£€0€ €0€ €0€ €hX¡€0€ €1QMW¡€remark 3: Refinement.¡€remark 3: Program : Dyana¡€*remark 3: Authors : Guntert,Wuthrich¡€Eremark 3: Other Refinement Remarks: Refinement Details Can Be Found¡€'remark 3: In The Jrnl Citation Above.¡€:remark 4: 1qmw Complies With Format V. 2.3, 09-July-1998¡€Aremark 100: This Entry Has Been Processed By Ebi On 8-Oct-1999.¡€(remark 100: The Ebi Id Code Is Ebi-4180.¡€ remark 210: Experimental Details¡€0remark 210: Experiment Type : Nmr¡€0remark 210: Temperature (Kelvin) : 283¡€0remark 210: Ph : 4.2¡€1remark 210: Ionic Strength : Null¡€1remark 210: Pressure : Null¡€=remark 210: Sample Contents : 90% Water10% D2O¡€Cremark 210: Nmr Experiments Conducted : Cosy,Tocsy,Noesy,Hsqc,¡€remark 210: 2d J Resolved¡€Cremark 210: Spectrometer Field Strength : 500mhz, 600mhz, 600mhz¡€Bremark 210: Spectrometer Model : Unity Plus 500, Unity¡€remark 210: 600, Amx600¡€Cremark 210: Spectrometer Manufacturer : Varian, Varian, Bruker¡€$remark 210: Structure Determination.¡€1remark 210: Software Used : Dyana¡€Bremark 210: Method Used : Torsion Angle Dynamics¡€0remark 210: Conformers, Number Calculated : 50¡€0remark 210: Conformers, Number Submitted : 36¡€Fremark 210: Conformers, Selection Criteria : Lowest Energy Structures¡€>remark 210: Best Representative Conformer In This Ensemble : 1¡€Fremark 210: Remark: The Structure Was Determined From A 2d Homonuclear¡€7remark 210: Noesy Spectrum With A Mixing Time Of 250ms.¡€remark 215: Nmr Study¡€Fremark 215: The Coordinates In This Entry Were Generated From Solution¡€Aremark 215: Nmr Data. Protein Data Bank Conventions Require That¡€Cremark 215: Cryst1 And Scale Records Be Included, But The Values On¡€*remark 215: These Records Are Meaningless.¡€CDbref 1qmw A 1 13 Sws P15471 Cxa1_const 1 13¡€8Link C Cys A 13 N Nh2 A 14£€0€ €0€ € €6ù¡€¡€0€ €Ô¡€¢€¢€0€ €Protein Data Bank¡€ €¡€0€ €Ô¡€¢€¢€¡€0€ €PDB¡€¡€1QMW£€¡€0€ €Ï¡€ ¢€¤€¡€0€ €0€ € €0€0€ €¡€0€ €Benie£€ A.J.Benie¤€A.J.0€ €¡€0€ €Whitford£€ D.Whitford¤€D.0€ €¡€0€ € Hargittai£€ B.Hargittai¤€B.0€ €¡€0€ €Barany£€G.Barany¤€G.0€ €¡€0€ €Janes£€ R.W.Janes¤€R.W.¡€0€ €¡€0€ €Ï¡€ ¢€¤€«€1€¤€0€ €1€ €)Solution structure of alpha-conotoxin SI.¡€0€ € €0€0€ €¡€0€ €Benie¤€A.J.0€ €¡€0€ €Whitford¤€D.0€ €¡€0€ € Hargittai¤€B.0€ €¡€0€ €Barany¤€G.0€ €¡€0€ €Janes¤€R.W.¡€ €‚Molecular and Cellular Biology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, University of London, UK.¢€ €0€ €1€¤€ FEBS Lett.¥€ FEBS Lett§€ 0014-5793 € FEBS letters.¡€0€ €¡€0€ €С€¢€¡€476¢€3£€287-295¨€eng£€1€ €¦‡^£€6åµ¢€0€ €0€ €(Solution Structure Of Alpha-Conotoxin Si¡€ Conotoxin¢€ÊMol_id: 1; Synthetic: Yes; Organism_scientific: Conus Striatus; Organism_common: Striated Cone; Organ: Venom Duct; Secretion: Venom Component; Other_details: Synthesised By Solid Phase Peptide Chemistry£€ÐSolution Structure Of Alpha-Conotoxin Si Conotoxin, Nicotinic Acetylcholine Receptor, Toxin, Venom Mol_id: 1; Molecule: Alpha-Conotoxin Si; Chain: A; Synonym: Si (2-7,3-13); Other_details: Amidated C-Terminus§€ÿ¡€0€0€ €¡€0€ €A£€SEQRES¨€¥€0€¢€0€ €Conus striatus¡€ striated cone£€1€0€ €taxon¡€ €]¥€0€ € €0€ €Conus¡€striatus£€bEukaryota; Metazoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus¤€¥€¦€INV¢€«€šn+£€0€0€ €¡€ 1 ¢€ €0€ €¡€ 2 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€ 0€ €¡€ 3 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€ 0€ €¡€ 4 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€0€ €¡€ 5 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€+0€ €¡€ 6 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€0€ €¡€ 7 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€ 0€ €¡€ 8 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€0€ € ¡€ 9 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€+0€ € ¡€ 10 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€"0€ € ¡€ 11 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€70€ € ¡€ 12 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€.0€ € ¡€ 13 ¢€¢€0€ €¡€0€ €Standard residue dictionary¡€ €¡€ 0€ €¡€ 14 ¢€ €¤€0€0€ €0€ €¡€¢€¡€0€ €¡€¢€0€ €0€ €¡€¢€¡€0€ €¡€¢€0€ €0€ €¡€¢€¡€0€ €¡€¢€0€ €0€ €¡€¢€¡€0€ €¡€¢€0€ €0€ €¡€¢€¡€0€ €¡€¢€0€ €0€ €¡€¢€¡€0€ €¡€¢€0€ €0€ €¡€¢€¡€0€ €¡€¢€0€ €0€ €¡€¢€¡€0€ €¡€ ¢€0€ €0€ €¡€ ¢€¡€0€ €¡€ ¢€ 0€ €0€ €¡€ ¢€¡€0€ €¡€ ¢€0€ €0€ €¡€ ¢€¡€0€ €¡€ ¢€0€ €0€ €¡€ ¢€¡€0€ €¡€ ¢€0€ €0€ €¡€ ¢€¡€0€ €¡€¢€0€ €0€ €¡€¢€ ¡€0€ €¡€¢€ 0€ €0€ €¡€¢€ ¡€0€ €¡€ ¢€ £€0€0€ €¡€0€ €ILE NH3+£€¢€£€0€X¤€0€0€ €¡€ N ¢€0€ N £€ 0€ €¡€ CA ¢€0€ CA £€ 0€ €¡€ C ¢€0€ C £€ 0€ €¡€ O ¢€0€ O £€ 0€ €¡€ CB ¢€0€ CB £€ 0€ €¡€ CG1¢€0€ CG1£€ 0€ €¡€ CG2¢€0€ CG2£€ 0€ €¡€ CD1¢€0€ CD1£€ 0€ € ¡€ H1 ¢€0€ H1 £€ 0€ € ¡€ H2 ¢€0€ H2 £€ 0€ € ¡€ H3 ¢€0€ H3 £€ 0€ € ¡€ HA ¢€0€ HA £€ 0€ € ¡€ HB ¢€0€ HB £€ 0€ €¡€1HG1¢€0€1HG1£€ 0€ €¡€2HG1¢€0€2HG1£€ 0€ €¡€1HG2¢€0€1HG2£€ 0€ €¡€2HG2¢€0€2HG2£€ 0€ €¡€3HG2¢€0€3HG2£€ 0€ €¡€1HD1¢€0€1HD1£€ 0€ €¡€2HD1¢€0€2HD1£€ 0€ €¡€3HD1¢€0€3HD1£€ ¥€0€0€ €¡€¢€ÿ0€ €¡€ ¢€ÿ0€ €¡€ ¢€ÿ0€ €¡€ ¢€ÿ0€ €¡€¢€ÿ0€ €¡€¢€ÿ0€ €¡€ ¢€ÿ0€ €¡€¢€ÿ0€ €¡€¢€ÿ0€ €¡€¢€ÿ0€ €¡€ ¢€ÿ0€ €¡€¢€ÿ0€ €¡€¢€ÿ0€ €¡€¢€ÿ0€ €¡€¢€ÿ0€ €¡€¢€ÿ0€ €¡€¢€ÿ0€ €¡€¢€ÿ0€ €¡€¢€ÿ0€ €¡€¢€ÿ0€ €¡€0€ €NH2 COOH£€¢€£€0€X¤€0€0€ €¡€ N ¢€0€ N £€ 0€ €¡€1HN ¢€0€1HN £€ 0€ €¡€2HN ¢€0€2HN £€ ¥€0€0€ €¡€¢€ÿ0€ €¡€¢€ÿ£€0€0€ €¡€0€ €PDB secondary structure¢€0€0€ €¡€ 1¢€¤€ €¡€¡€0€0€ €¡€¢€0€ €¡€ 2¢€¤€ €¡€¡€0€0€ €¡€¢€ ¤€0€0€ €¡€¢€0€ €QSingle-coordinate-per-atom model from PDB entry 1QMW with a vector model attached¢€Nmr, 36 Structures£€,FEB 5 4 Typographical~AUG 25 0 Initial Entry£€0€ € ¤€0€0€ €¢€ € €0€ €±¡€0€ €±¡€0€¢€0€                                                                              £€0€                                               ¢€0€ €è¡€0€ßƒcþ†ÿ (üo——bþ8ü/ ÄJ»þ‘ü^ørÿ û%ù ûÝý^øuŽøÆïôñœî¡éÔî ì2ñÛô·ïÿêñ™ïKóB÷øí×è å-æzõëÒî¸ð3éâÀñ$ôpöÆûðèëYë“÷zñŸñ é‹è÷é±é’óÍõ‡ú)ü²ðóðJöËïØí¢òû ÿg‡–þÄøvù ÿ@ÿSÜ+¹ Q [Ú ÕÅ-Ç€üʸD𧉤H~ » &d 5 ¬Èä  ³+ ^ | n§ “Ú E‚ -ÖQ qTóý&³ùø…ûÏøÏ ž!­ 7ûÄ~ö,Úõ±—ÿ‹ ÏýW  ôánÕüpü¼ù?÷9ño üÔ÷÷#ïm¢€0€'V<à.PÒŸÜ—ûfÑhçí„J#±= 9 $º†_Ó Š À¸E öμ q T Ú£! XþžùuõVö&øUööö°ö þ¶ù†û»õökõ5ðãì¤é¡ç•éLêÄïÊî å'êç§ëMïSòøéuæ»é¦ç¯æ5ë"âÖêäoãÁîKñï+ï©÷8ú!ïÝñ^÷ƒù‚ì¯êFîñµìMæÏèüí$ðtõ®øÝíGéèæñUï»ëŒéñåLérå$öfû/þ&uùüþòþ¹è®óËý”÷ø?Yÿkú³ôÿY§×ø#û¹þ ÑúûÒþû'ÈüÖÿ¨ø7ÿötùþ ù[—üV¦g jÕ‚5KŽ  ÌÙ!f2L# €fþ i s£€0€ó€ø9öÿò”üSù±þýýÜñeôvñXùºÿ:÷B÷GýÈýÞ6‡üŸþiúýúcÌ÷‹õþ”÷ñôLú6¦ŸXU=þƒ€ùtë©9þ;ý½ŠøÛGaûÓüÂõéø!¦ vÜ: Ý b: x 2ÿ Þp ; ûôùõúø&[ýö¸ú%ôÝû¡ù½ûÀù9û]ù®þŠõ|“ùŠF¨×Mq˜ÿPÿ üqû‰ü ù,û‚¥ùMþ¬õù“ø„ý\ûPøÓü”ûbóŠð?ìÒç^çüøñrô%òÍíÌì‚î¦åèäªêÝäç? ü6 © Z ò \SJ_ý#¼ Ë ¹±VÃE& Ü õ®F zsâA^ypýnƒ‘ =ÿ~+^¡€1€ €0€ €1€®€0€ €1QMW¡€A¢€¡€0€ €Ï¡€ ¢€«€šn+¡€1€´€0€ €¡€0€ €Ï¡€ ¢€¡€ Conotoxin¢€0€(Solution Structure Of Alpha-Conotoxin Si£€0€ÊMol_id: 1; Synthetic: Yes; Organism_scientific: Conus Striatus; Organism_common: Striated Cone; Organ: Venom Duct; Secretion: Venom Component; Other_details: Synthesised By Solid Phase Peptide Chemistry¤€Nmr, 36 Structures¶€0€¢€0€ €Conus striatus¡€ striated cone£€1€0€ €taxon¡€ €]¥€0€ € €0€ €Conus¡€striatus£€bEukaryota; Metazoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus¤€¥€¦€INV¢€0€ € ¡€ ¢€¦€¡€AXCCNPACGPKYSCX¢€0€ €0€¡€0€ € ¡€ ¢€ £€0€ €'¡€ˆ¢€ˆ£€ˆ¤€'¢€0€ € ¡€ ¢€ £€0€ €'¡€ˆ¢€ˆ£€ˆ¤€'£€0€ €¡€ ¢€ £€0€ €'¡€ˆ¢€ˆ£€ˆ¤€'¤€0€ €¡€ ¢€ £€0€ €'¡€ˆ¢€ˆ£€ˆ¤€'¥€0€ €¡€ ¢€ £€0€ €'¡€ˆ¢€ˆ£€ˆ¤€'¦€0€ €¡€ ¢€ £€0€ €'¡€ˆ¢€ˆ£€ˆ¤€'§€0€ €¡€ ¢€ £€0€ €'¡€#(¢€#(£€'¤€'¨€0€ €¡€ ¢€ £€0€ €'¡€ˆ¢€ˆ£€ˆ¤€'©€0€ €¡€ ¢€ £€0€ €'¡€ˆ¢€ˆ£€ˆ¤€'ª€«€0€ €'¡€$T¢€|£€ô¤€'¬€­€0€ €'¡€¢€£€¤€'®€'¯€'°€ ±€в€ ¸³€ ¸´€FPµ€N ¶€ˆ·€0€ €¡€ ¢€ £€¤€¸€0€ €¡€ ¢€ £€¤€¹€£€0€¡€0€ € 31.5285802798277¡€ 0.610865238198015¢€ 0£€ 0¤€ 14.5515172041013¥€ 49.2112886641296¦€0€ € 1¡€ 0¢€ 0£€ 0¤€ 0¥€ 1¦€ 0§€ 0¨€ 0©€ 0ª€ 1«€ 0¬€ 0.159898310899735­€ 0.25622034072876®€ -0.164774015545845¯€ 1§€0€ € -0.159898305084746¡€ -0.256220338983051¢€ 0.164774011299435